Introduction

• Adrenomedullin (ADM) is a bioactive peptide with diverse functions in human physiology.
• Identified in 1993 in human pheochromocytoma tissue as a 52 amino acid peptide.
• Significant implications in both health and disease.

Molecular Structure and Biosynthesis

• Produced as a prohormone and undergoes translational modifications to form the active peptide.
• Encoded by the ADM gene, made by cell types like endothelial and smooth muscle cells.
• Belongs to the calcitonin gene-related peptide (CGRP) family, sharing structural similarities.
• Interaction with calcitonin receptor-like receptor (CLR) and receptor activity modifying proteins (RAMPs) via intricate signalling pathways.

Cardiovascular and Hemodynamic Regulation

• Acts as a strong vasodilator, controlling blood pressure and maintaining vascular balance.
• Causes muscle relaxation and vasodilation through nitric oxide production and cyclic AMP increase.
• Offers protection against vascular dysfunction and inflammation.

Inflammatory Response and Immune Modulation

• Regulates inflammation with both pro-inflammatory and anti-inflammatory traits.
• Reduces production of inflammatory substances while encouraging anti-inflammatory agents.
• Impacts blood cell movement, reduces oxidative stress, and regulates immune cell activation.

Pathological Implications and Future Research Directions

• Monitoring ADM levels in the bloodstream connected to severity of illnesses like heart failure and cancers.
• Future research areas:
• Creating ADM-based treatment strategies.
• Exploring ADM processes.
• Investigating ADM as a diagnostic and prognostic tool.
• Examining ADM's impact on personalized medicine strategies.

Suitable ELISA Kits

• Adrenomedullin ELISA Kit