MASP2: A key serine protease in complement activation with complex roles in immunity:

Structure and Function:

• Six-domain protein crucial in lectin pathway
• Activates complement cascade by splitting C4 and C2
• Triggers C3 convertase formation
• Precisely controls immune response

Disease Implications:

• Linked to autoimmune disorders
• Impacts heart-related conditions
• Influences tissue damage and infection susceptibility
• Genetic variations affect disease severity

Diagnostic Potential:

• Indicates health conditions like sepsis
• Predicts disease outcomes
• Enables personalized medicine approaches
• Helps assess complement system activation

Therapeutic Targeting:

• Approaches include: Monoclonal antibodies, RNA-based therapies
• Promising results in: Microangiopathies, Ischemia reperfusion injury

Challenges remain in blocking MASP2 while preserving immune functions, driving ongoing innovative research to develop more effective treatments.

Suitable ELISA Kits

• MASP2 ELISA Kit
• Mannan-Binding Lectin Serine Protease 2 ELISA Kit