Myostatin (MSTN/GDF-8): The Body's Natural Growth Regulator
Endocrinology Diagnostics
Key Points about Myostatin (MSTN/GDF-8):
Protein Characteristics
- TGF-beta superfamily member
- 375 amino acid prepropeptide
- Primarily expressed in skeletal muscle
Biological Function
- Negative muscle mass regulator
- Inhibits muscle cell differentiation
- Controls muscle fiber size
- Modulates metabolism
Mechanism of Action
- Binds to ActRIIB receptor
- Triggers SMAD transcription factors
- Regulates muscle-specific gene expression
Clinical Significance
- Natural mutations enhance muscle growth
- Observed in humans and animals
Therapeutic Potential
- Muscle wasting conditions treatment
- Muscular dystrophy
- Sarcopenia
- Metabolic disorder management
Research Directions
- Myostatin inhibitors
- Anti-myostatin antibodies
- Gene therapy
- Personalized medicine approaches
Myostatin plays a critical role in muscle growth regulation, with significant implications for medical and agricultural applications.
Suitable ELISA Kits
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