Genome Editing Services

In this relatively new form of genetic engineering, DNA is inserted, replaced, or removed from a genome using artificially engineered nucleases, or "molecular scissors." The nucleases create specific double-stranded break (DSBs) at desired locations in the genome, and harness the cell’s endogenous mechanisms to repair the induced break by the cellular processes of homologous recombination (HR) and nonhomologous end-joining (NHEJ). Genome editing nucleases are engineerable to modify their DNA-binding specificity and can in principle cut any targeted position in the genome. This allows modification of the endogenous genes sequences that are impossible to specifically target by conventional RNAi. Stratech’s offering includes 3 different genome editing systems from SBI: